Scientific Affairs Manager - Italy (Rome)

Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to learn, adapt, and our tenacity to overcome barriers, together. Opportunity Overview As a member of the Rhythm Italy field-based Medical Affairs team, the Scientific Affairs Manager (SAM) will focus on advancing medical and scientific initiatives in rare MC4R pathway diseases. In close collaboration with the national and international Medical Affairs teams, the SAM will provide scientific and medical leadership and support for the implementation of integrated tactical and engagement plans, while upholding the highest standards of compliance and scientific integrity in Italy. You will be responsible for building peer-to-peer relationships with Key External Experts (KEEs) and other stakeholders to deliver clinical, scientific, and medical education. Further, you will support research initiatives, advisory boards, and other compliant scientific exchange activities to support the integrated strategic and tactical plan and the Medical Affairs’ tactics. Responsibilities and DutiesServe as a Scientific Affairs Manager for Italy and as a member of the international Medical Affairs Team Be a subject-matter expert for the MC4R pathway diseases and our indications Contribute to the development and implementation of the integrated strategic and tactical plan with a focus on the medical and scientific projects and tactics. Organize and lead local advisory boards and KEE meetings to gain insights, foster scientific exchange and support the local strategy. Provide medical support for the implementation of the local strategy. Build and maintain peer-to-peer relationships with external experts and stakeholders, delivering clinical, scientific, and medical education. Oversee and initiate medical projects in collaboration with clinical partners and research networks. Identify stakeholders and provide insights for future clinical developments and play a key role in the pre-launch and launch phase for these new developments. Contribute to the development and implementation of scientific communication plans and medical information materials, ensuring compliance with local regulatory requirements. Identify knowledge gaps among healthcare professionals and organize non-promotional scientific presentations. Participate in local medical and cross-functional projects and initiatives. Ensure effective and compliant communication with internal and external stakeholders. Establish genetic testing initiatives in collaboration with HCPs and obesity treatment networks Support the commercial team and HCPs with knowledge building around the efficacy and safety of our product including AE/PV reporting. Play a pivotal role in establishing appropriate multidisciplinary care including patient support programs Play a pivotal role in identifying hurdles and solutions in order to optimize patient identification and referral pathways. Communicate key medical insights from KEEs and others to inform medical strategy Collaborate effectively across internal stakeholders (including Medical Affairs, Commercial and others) to ensure aligned execution, consistent communication, and compliance with company, legal, and regulatory requirements; contribute to Customer Relationship Management (CRM) documentation as appropriate. Respond to unsolicited requests for medical information in a timely manner. Ensure that an accurate and fair-balanced response is provided Qualifications and SkillsAdvanced degree in a pharmaceutical, scientific, or medical field (PharmD, PhD, MD) 8 or more years’ experience within a Medical Science Liaison or similar field facing role with primary emphasis on field based scientific exchange within the biopharmaceutical industry. Relevant pharmaceutical and clinical/therapeutic experience also a consideration Rare diseases experience is a plus Launch experience is a plus Cross-functional mindset focused on a seamless collaboration with the commercial team Excellent communication and presentation skills - fluent in local language for the market and in verbal and written English Demonstrated knowledge of regional/local specific healthcare systems, the evolving medical landscape, reimbursement and industry trends. Ability to work in collaboration with the international region and with a positive attitude. This role is field- based in Italy. Candidates applying must be willing and able to work primarily out of their home office. This role will involve up to 50% travel. The expected salary range for this position is € 70 000 – € 105 000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units. More About Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare melanocortin-4 receptor (MC4R) pathway diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism. At Rhythm Our Core Values Are

• We are committed to advancing scientific understanding to improve patients’ lives
• We are inspired to tackle tough challenges and have the courage to ask bold questions
• We are eager to learn and adapt
• We believe collaboration and ownership are foundational for our success
• We value the unique contribution each individual brings to furthering our mission